The investigation into the 2011 murder of one-time millionaire Lanny Horowitz, who was shot nine times while taking a shower in the bathroom of his upscale Jupiter, Florida home. Only three people were in the home at the time: Lanny Horowitz, his ex-wife Donna Horowitz, whom he had divorced twice, but had reconciled with, and his son, Radley, who also resided there. Both had strained relationships with Lanny.

Darryl Pinkins and Roosevelt Glenn: two Indiana men, a 1989 gang rape, and the DNA evidence at the time that did not tie either man to the crime. Yet, both were convicted, spending years in prison. They vowed they were innocent, but Prosecutors had evidence and a victim who said she could identify one of the five alleged attackers. Their cases drew the attention of Indiana law professor Fran Watson who, along with her students, continued to search for clues over a fifteen year period. Everything changed when a new technology called TrueAllele came along, which could separate the genetic mixture in DNA evidence.